anti-conjugated Quinolinic acid antibodies
Product Number:
AP063
Host:
Rabbit
Clonality:
Polyclonal
Target :
Conjugated Quinolinic acid
Immunogens :
Synthetic Quinolinic acid conjugated to proteins carriers
Quantity :
100µl
Isotype :
IgG
Purity :
previously preabsobed on protein carriers, and purified
Form :
Lyophilized
Tested applications :
Immonhistochemistry, Immunocytochemistry. Optimal dilutions should be determined by each laboratory for each application
Research areas :
Neuroscience, Alzheimer disease
Storage instructions :
Lyophilized vial must be stored at 4°C in a dry area. After reconstitution with 50μl of distilled water and 50μl of glycerol, the aliquot can be stored at -20°C, and is stable at least 2 years.
Specificity :
Using a conjugate Quinolinic acid-BSA, antibody specificity was performed with an ELISA test by competition experiments with the following compounds :
| Compounds | Cross-reactivity ratio(a) |
|---|---|
| Quinolinic acid-BSA | 1 |
| Kynurenic-BSA | 1/>50,000 |
| L.Kynurenine-BSA | 1/>50,000 |
| Picolinic acid-BSA | 1/>50,000 |
| Quinaldic acid-BSA | 1/>50,000 |
| Xanthurenic acid-BSA | 1/>50,000 |
| Anthranilic acid-BSA | 1/>50,000 |
| 3OH-Anthranilic acid-BSA | 1/>50,000 |
| Phenylalanine-BSA | 1/>50,000 |
(a) : Quinolinic acid-BSA concentration/Other conjugated close related compounds concentration at half displacement.
BSA : Bovine Serum Albumin.
Corresponding antigen :
Gemacbio sells the corresponding antigen: Quinolinic acid(BSA) conjugate (catalog number: AG063)
References :
• GUILLEMIN G.J., BREW B.J., NOONAN C.E., TAKIKAWA O. and CULLEN K.M. Indoleamine 2.3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer’s disease hippocampus. Neuropathology and Applied Neurobiology (2005) 31, 395-404.
• GUILLEMIN GJ, CULLEN KM, LIM CK, SMYTHE GA, GARNER B, KAPOOR V, TAKIKAWA O, BREW BJ. Characterization of the kynurenine pathway in human neurons. J. Neurosci. (2007) 27(47):12884-92.
For all questions about price and availability of this product, please send us an email specifying your needs. We will immediately send you back a detailed estimate. ab [at] gemacbio [dot] com
